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Aristotle

"Metaphysics"


Anaxagoras of Clazomenae, who, though older than Empedocles, was
later in his philosophical activity, says the principles are
infinite in number; for he says almost all the things that are made of
parts like themselves, in the manner of water or fire, are generated
and destroyed in this way, only by aggregation and segregation, and
are not in any other sense generated or destroyed, but remain
eternally.
From these facts one might think that the only cause is the
so-called material cause; but as men thus advanced, the very facts
opened the way for them and joined in forcing them to investigate
the subject. However true it may be that all generation and
destruction proceed from some one or (for that matter) from more
elements, why does this happen and what is the cause? For at least the
substratum itself does not make itself change; e.g. neither the wood
nor the bronze causes the change of either of them, nor does the
wood manufacture a bed and the bronze a statue, but something else
is the cause of the change. And to seek this is to seek the second
cause, as we should say,-that from which comes the beginning of the
movement. Now those who at the very beginning set themselves to this
kind of inquiry, and said the substratum was one, were not at all
dissatisfied with themselves; but some at least of those who
maintain it to be one-as though defeated by this search for the second
cause-say the one and nature as a whole is unchangeable not only in
respect of generation and destruction (for this is a primitive belief,
and all agreed in it), but also of all other change; and this view
is peculiar to them.


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